Topical exosome biologics
Exosome and secretome products from 3D bioreactor culture, for licensed MD, DO, NP and PA practices. NTA-verified particle counts and a dual-lab Certificate of Analysis on every lot.
- FDA-Registered Facility
- cGTP-Compliant (21 CFR Part 1271)
- Dual-Lab COA Verified
- NTA-Verified
- USA Manufactured
Topical cosmetic use only · No minimum order
The product line
Every lot ships with dual-lab COA documentation and an NTA particle report, frozen on dry ice with temperature monitoring.
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Topical cosmeticBest seller3DEXO+ 77B Exosome Matrix
Exosome matrix from 3D bioreactor-cultured Wharton's jelly MSCs.
- Particles
- 77 billion (NTA)
- Volume
- 1 mL
- Culture
- 3D bioreactor
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Topical cosmeticDermal Papillary Secretome Matrix+ 150B
High-concentration topical secretome matrix.
- Particles
- 150 billion (NTA)
- Volume
- 1.8 mL
- COA
- Dual-lab
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Topical cosmeticNovaRenew Secretome System
A two-vial topical system: the Nova Core concentrate as step one, paired with the Renew step-two matrix.
- Format
- Two-vial kit
- Step one
- Nova Core concentrate
- Verification
- NTA, dual-lab COA
All products are sold as topical cosmetic products. Compare pricing on the Biologics collection.
Made in three dimensions
Our exosome lines start in hollow-fiber bioreactors rather than flat flasks: one closed, controlled vessel instead of stacks of separate ones. Published studies report 7.5× to 20× more extracellular vesicles per run from 3D culture than from matched 2D flasks.
- Xeno-free, serum-free culture: no animal serum and no FBS.
- pH, oxygen and temperature controlled for the whole vessel.
- Particle concentration and size measured on every finished lot.
Counted, not estimated
Every lot includes a NanoSight nanoparticle tracking analysis (NTA) report: a laser-based count and size distribution of the particles in the final product, not a protein-based estimate.
- Concentration in particles per mL, corrected for dilution.
- Size distribution, including mean, mode and D10–D90 range.
- Labeled count = concentration × fill volume.
Included with every order
Lot documentation is available to review before you order.
- Dual-lab COA
- Lot-specific Certificates of Analysis from two independent laboratories.
- NTA report
- NanoSight particle concentration and size distribution for the lot.
- Sterility & endotoxin
- Sterility by direct inoculation (21 CFR 610.12) and endotoxin by LAL (USP <85>).
- Mycoplasma screening
- Reported on the lot's Certificate of Analysis.
- Cold-chain records
- Stored at −80 °C; shipped frozen on dry ice with temperature monitoring.
- Account manager
- One contact for ordering, documentation requests and product questions.
Regulatory status, plainly
What these products are, and what they are not.
- StatusTopical cosmetic products. Not drugs and not FDA-approved.
- UseTopical cosmetic use only. Product selection is clinician-directed.
- ManufacturingFDA-registered facility, cGTP-compliant (21 CFR Part 1271), USA manufactured.
- GuidanceStem Nova Network provides product documentation and education, not dosing or procedural guidance.
- BuyersLicensed MD, DO, NP and PA practices only, verified before ordering.
Exosome questions
More in the full FAQ.
What does NTA particle verification mean?
Nanoparticle tracking analysis tracks individual particles with a laser to count and size them. Every lot ships with a NanoSight NTA report showing particle concentration and size distribution for that lot.
How is 3D bioreactor culture different from 2D?
In 2D culture, cells grow as a single layer on flat flasks. In 3D hollow-fiber bioreactors, cells grow in a closed, controlled vessel with far more surface area. Published studies report higher extracellular vesicle yield per run from 3D culture; see the 3D culture page for the data.
How are exosome products stored and shipped?
They are stored at −80 °C and shipped frozen on dry ice with temperature monitoring. Each shipment includes storage and handling documentation.
How are these products classified?
They are topical cosmetic products. They are not drugs and are not FDA-approved.
Which product is right for my practice?
That depends on your practice's format and volume needs. Our team can walk you through each product's specifications and documentation; contact us or apply for a wholesale account to start.
Who is eligible to purchase?
Licensed medical professionals (MD, DO, NP, PA) and their practice entities. Every applicant is verified before approval, typically within 24 hours. There is no minimum order.
Before you choose a supplier
Cited explainers and sourcing guides for licensed practitioners.
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Science LibraryExosomes & EVsWhat EVs are, and how they are separated and counted.
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Science Library2D vs. 3D cultureWhat changes in manufacturing, and the published yield data.
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Guide10-point supplier checklist
The questions to ask any wholesale exosome supplier.
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GuideLyophilized vs. liquid
How preservation format affects what arrives in the vial.
Also available: hUCT-MSC
25 million umbilical cord tissue-derived MSCs per vial with 97% post-thaw viability and dual-lab COA. Individualized biologic, not FDA-approved.
Explore hUCT-MSC
Source with the paperwork in hand
Apply for a wholesale account to review lot-specific COAs and order. Licensed professionals only, no minimum order, and applications are typically approved within 24 hours.
For licensed medical professionals only. Exosome products are topical cosmetic products. hUCT-MSC products are individualized and not FDA-approved; use is clinician-directed, and patients should consult their primary care provider. Stem Nova Network does not provide dosing or procedural guidance. Products are not intended to diagnose, treat, cure, or prevent any disease. Stem Nova Network is a DBA of D1D Enterprises, Inc.