NovaRenew™ — Topical Cosmetic Secretome System for Licensed Professionals

About This Product

NovaRenew™ is a two-step topical cosmetic secretome system supplied exclusively to licensed medical professionals. It pairs Nova Core — a 3D bioreactor-cultivated secretome concentrate — with Renew — a conditioning formulation — to support post-procedure cosmetic protocols including microneedling, RF microneedling, laser resurfacing, and chemical peels.

For topical cosmetic use only. Not for injection or therapeutic use. Not FDA-approved.

The Two-Step System

• Step 1 — Nova Core (Concentrate): 3D bioreactor-cultivated secretome applied to the treatment zone as part of the procedure.
• Step 2 — Renew (Conditioning Formulation): applied after treatment to condition and support the post-procedure skin environment.

Why 3D Bioreactor Culture

Nova Core's secretome is produced in a 3D bioreactor culture environment rather than conventional 2D flat-surface cell culture, which allows source cells to grow in three dimensions. This is a manufacturing process distinction, not a clinical outcomes claim.

Product Specifications

• Two-step system — Nova Core (3D bioreactor-cultivated secretome concentrate) paired with Renew (conditioning formulation)
• Derived from ethically sourced human cells — cell-free secretome, no live or viable cells
• Shelf-stable — approximately 6 months frozen in a standard freezer; 2–3 weeks refrigerated; no cryo freezer required
• Liquid, stabilized formulation — not lyophilized
• Consistent batch quality — sterility, mycoplasma, and endotoxin tested prior to release
• Dual-lab Certificate of Analysis with every order — full documentation
• cGTP-compliant facility (21 CFR Part 1271) · FDA-registered · USA manufactured

Quality & Testing

Every lot is released with a dual-lab Certificate of Analysis covering sterility, mycoplasma, and endotoxin. Documentation is available upon request before purchase.

cGTP compliance (21 CFR Part 1271) and FDA facility registration are manufacturing and facility credentials. They do not constitute FDA approval of this product for any therapeutic indication.

Storage & Handling

Store frozen until use. NovaRenew™ is stabilized for approximately 6 months in a standard freezer — no cryogenic freezer required. In a frost-free freezer, insulate the vials within a frozen mass (e.g., surrounded by ice or frozen gel packs) to buffer defrost cycles. Do not refreeze after thawing.

Suggested Protocol Cadence

Once monthly for three months, followed by maintenance approximately four times per year. Final protocol is at the practitioner's sole discretion.

How to Order

NovaRenew™ is available to licensed medical professionals only. Credential verification is required prior to purchase.

1. Apply for wholesale access at stemnovanetwork.com/apps/wpdapp
2. Credential verification completed within 24 hours in most cases
3. Once approved, wholesale pricing and volume tiers are unlocked immediately
4. Dual-lab CoA provided with every order

Contact partners@stemnovanetwork.com with any questions.

Frequently Asked Questions

What is the shelf life and storage requirement?
NovaRenew™ is stabilized for approximately 6 months frozen in a standard freezer and 2–3 weeks refrigerated — no cryogenic freezer required. Do not refreeze after thawing.

How is NovaRenew applied?
NovaRenew™ is a two-step topical system. Step 1, Nova Core, is applied to the treatment zone during the procedure. Step 2, Renew, is applied afterward to condition and support the post-procedure skin environment. For topical cosmetic use only.

Is a Certificate of Analysis included with every order?
Yes. Every wholesale order includes a dual-lab, lot-specific CoA covering sterility, mycoplasma, and endotoxin. Documentation is also available on request before purchase.

What is the difference between 3D bioreactor and 2D flat culture?
2D flat-plate culture grows cells on a flat surface — the standard method, but one that does not replicate natural cellular conditions. 3D bioreactor culture allows source cells to grow three-dimensionally. This is a manufacturing process characteristic, not a clinical outcomes claim.

Is this product FDA-approved?
No. NovaRenew™ is not an FDA-approved drug or therapeutic agent. There are currently no FDA-approved exosome or secretome products. This product is supplied as a research-grade cosmetic biologic for licensed professional topical use only.

Regulatory Notice

This product is supplied as a research-grade cosmetic biologic for licensed professional use only. It is not an FDA-approved drug or therapeutic agent and is not intended to diagnose, treat, cure, or prevent any disease or condition. For topical cosmetic use only. Not for injection or therapeutic use. All professional application decisions are at the sole discretion of the licensed practitioner in accordance with applicable federal and state regulations.