3DExo+™ 12B Exosome Matrix — Topical Cosmetic Biologic for Licensed Professionals

About This Product

3DExo+™ 12B Exosome Matrix is a topical cosmetic exosome serum supplied exclusively to licensed medical professionals. Each 10 mL vial contains 12 billion NTA-verified extracellular vesicles derived from 3D bioreactor-cultured Wharton's Jelly UCT-MSCs, manufactured in the USA in an FDA-registered tissue establishment operating under cGTP-compliant standards (21 CFR Part 1271).

For topical cosmetic use only. Not for injection. Not FDA-approved.

Why 3D Bioreactor Culture

Most exosome products are produced using standard 2D flat-surface cell culture. Stem Nova Network uses 3D hollow-fiber bioreactor systems that allow cells to grow in three dimensions. Published research has documented up to 19.4x higher extracellular vesicle yield per cell from 3D bioreactor systems compared to conventional 2D flat culture. This is a manufacturing process distinction, not a statement about clinical use.

Product Specifications

• 12 billion EVs per vial — NTA-verified particle count, lot-documented
• Volume: 10 mL per vial
• 3D bioreactor-cultured source cells — Wharton's Jelly UCT-MSC origin
• First-pregnancy donors — full donor screening on record
• Classification: Topical cosmetic · Not for injection
• Lightweight serum format
• Xeno-Free · Serum-Free · Endotoxin-tested
• Cell-free matrix — no live or viable cells
• Manufactured in the USA in an FDA-registered tissue establishment operating under cGTP-compliant standards (21 CFR Part 1271)
• Lot-specific Certificate of Analysis with every order
• Sterility tested per 21 CFR 610.12 · Mycoplasma tested prior to release

Cosmetic Application Context

Licensed professionals incorporate this product into topical cosmetic workflows, including:

• Topical application after microneedling
• Professional facial and skincare services
• Topical application after laser and fractional resurfacing
• Topical application alongside LED light services
• Stand-alone topical cosmetic facial protocols

All professional application decisions are at the sole discretion of the licensed practitioner.

Quality & Testing

Every lot is independently tested and released with a Certificate of Analysis covering particle count via NTA, sterility, mycoplasma, endotoxin, and size distribution. Documentation is available upon request before purchase.

FDA registration of the manufacturing establishment and cGTP compliance (21 CFR Part 1271) are manufacturing and facility credentials. They do not constitute FDA approval of this product for any indication.

How to Order

3DExo+™ 12B is available to licensed medical professionals only. Credential verification is required prior to purchase.

• Apply for wholesale access at stemnovanetwork.com/apps/wpdapp
• Credential verification completed within 24 hours in most cases
• Once approved, wholesale pricing and volume tiers are unlocked immediately
• Lot-specific CoA provided with every order

Contact info@stemnovanetwork.com with any questions, or reach our team here.

Frequently Asked Questions

What is the shelf life and storage requirement?
3DExo+™ 12B ships liquid cryopreserved on dry ice. Store at -80°C or below upon receipt. Thaw at room temperature or in a 37°C water bath immediately before use. Use within 1 hour of thawing. Do not refreeze after thawing.

Is a Certificate of Analysis included with every order?
Yes. Every wholesale order includes a lot-specific CoA covering NTA particle count, sterility, mycoplasma, endotoxin, and size distribution. Documentation is also available on request before purchase.

What is NTA verification and why does it matter?
Nanoparticle Tracking Analysis (NTA) is an established method for measuring particle count and size distribution in an exosome preparation. NTA-verified counts reflect what is in the vial as shipped, not estimated or derived figures.

What is the difference between the 12B and 60B vials?
The 12B is a 10 mL topical cosmetic serum for facial and medspa protocols that need a larger application volume. The 60B is a higher concentration in a 1 mL vial. Both come from the same 3D bioreactor-cultured Wharton's Jelly UCT-MSC source and are for topical cosmetic use only.

Is this product FDA-approved?
No. 3DExo+™ 12B is not an FDA-approved drug or therapeutic agent. There are currently no FDA-approved exosome products. This product is supplied as a topical cosmetic product for licensed professional use only.

Regulatory Notice

This product is supplied as a topical cosmetic product for licensed professional use only. It is not an FDA-approved drug or therapeutic agent and is not intended to diagnose, treat, cure, or prevent any disease or condition. For topical cosmetic use only. Not for injection. All professional application decisions are at the sole discretion of the licensed practitioner in accordance with applicable federal and state regulations.