What makes the 150B Dermal Exosome Matrix different from 60B exosome products?

The Dermal Papillary Secretome Matrix+ delivers 150 billion exosomes per vial — more than twice the EV load of standard 60B serums. It is specifically formulated to target the papillary dermal layer with FGF, VEGF, PDGF, and TGF-b growth factors for enhanced collagen remodeling, angiogenesis, and skin regeneration.

What procedures is the 150B dermal exosome matrix designed for?

This product is designed for topical post-procedure use including: microneedling and RF microneedling, laser resurfacing, chemical peels, post-PRP/PRFM, hair restoration protocols, and surgical scar support. It is for topical cosmetic use only — not for injection.

Is the Dermal Papillary Secretome Matrix safe for all skin types?

This product is cell-free and non-viable, derived from ethically screened donors. It is xeno-free, serum-free, and immune-privileged by nature of its UCT-MSC origin. Application protocols and patient suitability are determined by the licensed provider.

How does topical exosome application support collagen production?

Exosomes derived from MSCs upregulate collagen-related genes including COL3A1, MMP1, and MMP3. They convert fibroblasts to myofibroblasts, promote scarless collagen deposition, and activate angiogenesis pathways resulting in improved skin texture, elasticity, and hydration.

Can the 150B dermal exosome matrix be used with PRP?

Yes. Many providers use exosomes in combination with PRP to amplify results. The exosome matrix can be applied topically following PRP/PRFM treatments to enhance signaling and tissue recovery. Protocol decisions are at provider discretion.

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Stem Nova

Dermal Papillary Secretome Matrix+ 150B — Topical Cosmetic Biologic for Licensed Professionals

Regular price: $2,500.00
Regular price
Sale price: $2,500.00

Tax included. Shipping calculated at checkout.

About This Product

Dermal Papillary Secretome Matrix+ is a topical cosmetic exosome biologic supplied exclusively to licensed medical professionals. Each 1.8mL vial contains 150 billion NTA-verified extracellular vesicles derived from 3D bioreactor-cultured Wharton's Jelly UCT-MSCs, sourced from an AATB-accredited, FDA-registered tissue establishment operating under cGTP standards (21 CFR Part 1271).

For topical cosmetic use only. Not for injection or therapeutic use. Not FDA-approved.

About This Formulation

Dermal Papillary Secretome Matrix+ is formulated for the papillary dermal layer — the uppermost layer of the dermis where fibroblasts, capillaries, and collagen fibres reside. The 1.8mL volume provides broader coverage than standard 1mL exosome serums and delivers 150 billion NTA-verified EVs — more than twice the EV load of standard 60B formats.

Designed for use with existing medspa and aesthetic workflows including microneedling, RF microneedling, laser resurfacing support, and post-procedure cosmetic recovery protocols.

Why 3D Bioreactor Culture

Stem Nova Network uses 3D hollow-fiber bioreactor systems rather than standard 2D flat-surface cell culture. Published research has documented up to 19.4x higher extracellular vesicle yield per cell from 3D bioreactor systems compared to conventional 2D flat culture. This is a manufacturing process distinction, not a clinical outcomes claim.

Products are liquid cryopreserved — not lyophilized — maintaining membrane integrity from manufacture through delivery.

Product Specifications

150 Billion EVs per vial — NTA-verified particle count, lot-documented
Volume: 1.8mL — suitable for full-area cosmetic protocols
3D bioreactor-cultured source cells — Wharton's Jelly UCT-MSC origin
First-pregnancy donors — full donor screening on record
Liquid cryopreserved — not lyophilized
Xeno-Free · Serum-Free · Endotoxin-tested
Cell-free matrix — no live or viable cells
Sourced from an AATB-accredited, FDA-registered tissue establishment operating under cGTP standards (21 CFR Part 1271)
Lot-specific Certificate of Analysis with every order
Sterility tested per 21 CFR 610.12 · Mycoplasma tested prior to release

Cosmetic Application Context

Licensed professionals incorporate this product into topical cosmetic workflows including:

Post-microneedling topical application
Post-RF microneedling cosmetic support
Post-laser resurfacing cosmetic recovery
Post-chemical peel topical support
Stand-alone topical cosmetic facial protocols

All professional application decisions are at the sole discretion of the licensed practitioner.

Quality & Testing

Every lot is independently tested and released with a Certificate of Analysis covering particle count via NTA, sterility, mycoplasma, endotoxin, and size distribution. Documentation is available upon request before purchase.

Sourcing from an AATB-accredited, FDA-registered tissue establishment operating under cGTP standards (21 CFR Part 1271) are manufacturing and facility credentials. They do not constitute FDA approval of this product for any indication.

How to Order

Dermal Papillary Secretome Matrix+ is available to licensed medical professionals only. Credential verification is required prior to purchase.

Apply for wholesale access at stemnovanetwork.com/apps/wpdapp
Credential verification completed within 24 hours in most cases
Once approved, wholesale pricing and volume tiers are unlocked immediately
Lot-specific CoA provided with every order

Contact partners@stemnovanetwork.com or call 281-541-0047 with any questions.

Frequently Asked Questions

What is the shelf life and storage requirement?
Ships liquid cryopreserved on dry ice. Store at -80°C or below upon receipt. Once thawed, use within the window specified on your lot CoA. Do not refreeze after thawing.

Is a Certificate of Analysis included with every order?
Yes. Every wholesale order includes a lot-specific CoA covering NTA particle count, sterility, mycoplasma, endotoxin, and size distribution. Documentation is available on request before purchase as well.

How does the 150B differ from the 3DExo+™ 60B?
The 150B vial contains 150 billion NTA-verified EVs in a 1.8mL volume — more than twice the EV count of the 60B vial and a larger volume for broader coverage. Both are topical cosmetic exosome biologics for licensed professional use only.

Is this product FDA-approved?
No. This product is not an FDA-approved drug or therapeutic agent. There are currently no FDA-approved exosome products. This product is supplied as a research-grade cosmetic biologic for licensed professional topical use only.

Regulatory Notice

This product is supplied as a research-grade cosmetic biologic for licensed professional use only. It is not an FDA-approved drug or therapeutic agent and is not intended to diagnose, treat, cure, or prevent any disease or condition. For topical cosmetic use only. Not for injection or therapeutic use. All professional application decisions are at the sole discretion of the licensed practitioner in accordance with applicable federal and state regulations.