Topical Cosmetic Exosome Biologics for Medspas & Aesthetic Clinics


Topical Cosmetic Biologics · Licensed Medspas Only · Credential Verification Required

Wholesale Exosome Biologics for Medspas & Aesthetic Practices

Stem Nova Network · For licensed medspas, aesthetic clinics, and dermatology practices · Credential verification required

3D-Cultured · NTA-Verified Every Lot · Topical Cosmetic Use Only · Device-Compatible

One supplier. Three SKUs. Documented every lot.

3D-cultured topical cosmetic exosome biologics for licensed medspas, aesthetic clinics, and dermatology practices. NTA-verified particle counts on every lot. Compatible with your existing microneedling, RF microneedling, laser, and dermaplaning protocols. For topical cosmetic use only — not for injection or therapeutic use.

AATB Accredited FDA-Registered Facility cGTP Compliant — 21 CFR Part 1271 NTA-Verified Every Lot Dual-Lab COA USA Manufactured
Important: These products are not FDA-approved drugs or therapeutic agents and are not intended to diagnose, treat, cure, or prevent any disease or condition. Stem Nova Network exosome biologics are supplied for topical cosmetic use only — they are not for injection or therapeutic use. All clinical decisions and protocol design are at the sole discretion and professional responsibility of the licensed practitioner.

Topical Cosmetic Exosome Products

Three exosome biologic SKUs supplied wholesale to licensed medspa and aesthetic practitioners. All three are 3D bioreactor-cultured, NTA-verified, and supplied for topical cosmetic application only.

Flagship · Topical Cosmetic

3DExo+™ Matrix — 60 Billion EVs

The flagship topical cosmetic exosome biologic. 60 billion NTA-verified extracellular vesicles in a 1mL lyophilized vial. Suited for full-face cosmetic protocols, post-procedure cosmetic recovery topical application, and aesthetic adjunctive use with microneedling, RF, laser, and dermaplaning.

SKU: SNN-EXO-60B-1ML · 1mL lyophilized · 60B NTA-verified EVs

Suggested retail: $1,500 – $2,500 per session

View Product Details →

Topical cosmetic use only · Not for injection · Not FDA-approved

Entry Tier · Topical Cosmetic

3DExo+™ Topical — 12 Billion EVs

The entry-tier topical exosome biologic. 12 billion NTA-verified extracellular vesicles in 10mL liquid format. Ideal for practices adding exosome biologics for the first time, smaller treatment areas, or spot cosmetic protocols. Same 3D culture standards as the flagship product.

SKU: SNN-EXO-12B-10ML · 10mL liquid · 12B NTA-verified EVs

Suggested retail: $800 – $1,400 per session

View Product Details →

Topical cosmetic use only · Not for injection · Not FDA-approved

Ultra-Potent · Topical Cosmetic

Dermal Papillary Matrix+ — 150 Billion EVs

The ultra-potent topical cosmetic exosome biologic. 150 billion NTA-verified extracellular vesicles in 1.8mL lyophilized vial. Designed for premium cosmetic protocols, signature service tiers, and high-density topical applications including scalp cosmetic use and full-face premium sessions.

SKU: SNN-DPM-150B-1.8ML · 1.8mL lyophilized · 150B NTA-verified EVs

Suggested retail: $3,500 – $8,000 per session

View Product Details →

Topical cosmetic use only · Not for injection · Not FDA-approved

How Medspas Integrate Topical Exosome Biologics

Topical cosmetic exosome biologics are designed to integrate with the equipment and protocols your medspa already runs. No new device purchases, no blood draws, no centrifuges. Protocol design and clinical application remain entirely at the discretion of the licensed practitioner.


  • Topical application following microneedling protocols
  • Post-procedure cosmetic recovery topical use
  • RF microneedling cosmetic adjunctive applications
  • Cosmetic laser resurfacing post-care topical protocols
  • Dermaplaning cosmetic finishing applications
  • Signature cosmetic facial service tier upgrade
  • Scalp cosmetic topical protocols (medspa hair-focused service lines)
  • Combination protocols with existing topical cosmetic offerings

Wholesale Economics: Margin & Pricing

Topical exosome cosmetic biologics position medspas at the premium tier of regenerative aesthetics. Wholesale pricing is available to enrolled practices upon credential verification. Below is an illustrative margin example based on the flagship 60B product at suggested retail. Actual session pricing, protocol design, and treatment frequency are determined by the licensed practitioner.


Illustrative Margin Example — 3DExo+™ Matrix 60B

Wholesale Cost
$550/vial
Suggested Retail
$1,500/session
Gross Margin
$950/session
@ 10 sessions/mo
$9,500/mo

Margin calculation excludes procedure fees, device costs, and per-session consumables. Suggested retail is illustrative and not binding. Final pricing is at the sole discretion of the licensed practitioner. Wholesale pricing is logged-in only and varies by SKU and order tier.

Positioning vs. PRP in Your Aesthetic Menu

Medspas already offering PRP commonly position topical exosome biologics as the premium tier above PRP — distinct service, distinct pricing, distinct positioning. Both can coexist in an aesthetic menu. The comparison below is operational, not therapeutic.

Operational Factor PRP Topical Exosome Biologic
Blood draw required Yes — patient venipuncture No — off-the-shelf biologic
Lot-to-lot consistency Varies 3–5x by patient NTA-verified every lot
Equipment needed Centrifuge, draw kit, tubes Existing devices only
Session prep time 15–25 min processing Reconstitution, <5 min
Documentation per session Patient-specific only Lot CoA + NTA report
Positioning tier Mid-tier aesthetic Premium aesthetic tier

Comparison reflects operational and supply-chain differences only. No therapeutic equivalence or superiority is claimed or implied. Both modalities have distinct clinical considerations that are at the discretion of the licensed practitioner.

Why Medspas Choose Stem Nova Network

NTA-Verified Every Lot

Nanoparticle Tracking Analysis confirms exosome particle count on every production lot — documented on your lot-specific CoA, not estimated or derived from input cell counts.

3D Bioreactor Culture

3D hollow-fiber bioreactor systems. Published research documents up to 19.4x higher EV yield per cell versus standard 2D flat culture. A manufacturing process distinction — not an outcomes claim.

AATB-Accredited Tissue Source

Donor source from an AATB-accredited, FDA-registered tissue establishment operating under cGTP standards (21 CFR Part 1271). Facility credentials — not product approval.

Dual-Lab COA Every Order

Every lot is tested both in-house and through an independent third-party laboratory. Both results must meet release criteria before a lot ships to your practice.

Compatible With Your Devices

Topical cosmetic exosome biologics integrate with the microneedling, RF microneedling, laser, and dermaplaning equipment your medspa already operates. No new device investment required.

Licensed Professionals Only

Credential verification required before any purchase is approved. We do not sell to unlicensed individuals or unapproved facilities. This protects your practice and our supply chain.

How Wholesale Access Works

Onboarding takes about 5 minutes to apply. Most medspas are approved within one business day. First orders typically ship within 2–3 business days of approval.


01

Submit Wholesale Application

Complete the credential verification form: medical license, NPI, practice name, and primary cosmetic application. Submission takes about 5 minutes. We review during business hours and typically respond within 24 hours.


02

Unlock Wholesale Pricing

Upon approval you receive logged-in access to tiered wholesale pricing, sample CoAs by SKU, NTA verification reports, Safety Data Sheets, and product specifications. A dedicated representative reaches out to walk through product fit and protocol integration questions.


03

Order & Receive in 2–3 Days

Place orders through your wholesale account. Biologics ship overnight on dry ice with cold-chain logging and chain of custody. Lot-specific CoA arrives with every shipment. Most first orders arrive within 2–3 business days of approval.

Frequently Asked Questions

Can a medspa use Stem Nova exosome biologics in injection protocols?

No. Stem Nova Network exosome biologics are supplied for topical cosmetic use only. They are not formulated, indicated, or supplied for injection or any therapeutic application. Cosmetic topical application alongside microneedling, RF microneedling, laser, or dermaplaning protocols is the intended use.

Do I need to buy new equipment to add exosome biologics to my medspa?

No. Stem Nova topical exosome biologics are designed to integrate with the equipment most medspas already operate — microneedling devices, RF microneedling, laser resurfacing, and dermaplaning. No new device purchases or workflow changes are required. Protocol design and clinical application remain at the discretion of the licensed practitioner.

What licenses qualify for Stem Nova wholesale enrollment?

Stem Nova Network supplies licensed medical professionals. For medspa applications, this typically includes medical directors, physicians, nurse practitioners, physician assistants, and other licensed practitioners operating under appropriate medical supervision. Credential verification is completed during enrollment. Contact us at info@stemnovanetwork.com or partners@stemnovanetwork.com with questions about your specific license type.

Can my medspa offer both PRP and topical exosome biologics?

Yes. Many medspas continue offering PRP at one tier while positioning topical exosome biologics as a premium tier above. Some practitioners use them in combination protocols. The approach, sequencing, and protocol design are entirely at the discretion of the licensed medical professional. Stem Nova provides the biologic; protocol design is your domain.

What documentation comes with every medspa order?

Every shipment includes a lot-specific Certificate of Analysis (tested both in-house and by an independent third-party laboratory), Nanoparticle Tracking Analysis verification report on request, Safety Data Sheet, storage and reconstitution specifications, and chain of custody documentation. Cold-chain logging is documented in transit.

What's the difference between the 60B, 12B, and 150B SKUs?

The 60B (3DExo+™ Matrix) is the flagship topical product — 60 billion NTA-verified exosomes in 1mL lyophilized format, suited for full-face cosmetic protocols. The 12B (3DExo+™ Topical) is the entry-tier option — 12 billion exosomes in 10mL liquid format, suited for smaller treatment areas, spot protocols, or practices adding exosome biologics for the first time. The 150B (Dermal Papillary Matrix+) is the ultra-potent tier — 150 billion exosomes in 1.8mL lyophilized format, designed for premium signature cosmetic protocols and high-density topical applications.

Are Stem Nova exosome biologics FDA-approved?

No. Stem Nova Network exosome biologics are not FDA-approved drugs or therapeutic agents. They are supplied for topical cosmetic use only. Our manufacturing partner operates an FDA-registered, AATB-accredited tissue establishment under cGTP standards (21 CFR Part 1271) — these are facility credentials, not product approval. All clinical decisions are at the sole discretion of the licensed practitioner.


Add Premium Exosome Biologics to Your Medspa Menu

Wholesale pricing, NTA-verified lot documentation, dual-lab CoAs, and dedicated representative support — available to licensed medspas upon credential verification. Most practices approved within one business day.

Regulatory Notice: Stem Nova Network exosome biologics are supplied as topical cosmetic biologics for licensed professional use only. These products are not FDA-approved drugs or therapeutic agents and are not intended to diagnose, treat, cure, or prevent any disease or condition. Stem Nova Network exosome biologics are not for injection or therapeutic use. All clinical decisions and protocol design are at the sole discretion and professional responsibility of the licensed practitioner in accordance with applicable federal and state regulations including 21 CFR Part 1271. Suggested retail pricing shown is illustrative only and not binding. Wholesale pricing is available to enrolled, credential-verified practices upon login.