What are 3D-cultured exosomes and why do they outperform 2D-cultured exosomes?

3D-cultured exosomes are produced in hollow-fibre bioreactor systems that mimic the natural cellular environment. This 3D environment generates up to 19.4x more exosomes and 15.5x higher concentrations compared to conventional 2D flat-flask cultures, resulting in a richer, more potent secretome payload for clinical protocols.

Are Stem Nova exosomes FDA approved?

No exosome products are currently FDA approved. Stem Nova exosomes are registered under an FDA Type II Drug Master File (DMF), which documents manufacturing processes and quality controls. Our products are supplied exclusively to licensed medical professionals for use within their professional scope and applicable state regulations.

What testing does each vial of 3DExo+ undergo?

Every vial is tested for: sterility (negative), endotoxin (< 10 EU/mL via LAL per USP 85), mycoplasma (negative), particle count via NTA (Nano Tracking Analysis), and lot-specific release criteria. Products are double-lab tested in-house and through an independent third-party laboratory.

Who can order 3DExo+ 60B exosomes from Stem Nova Network?

Products are available exclusively to licensed medical professionals including physicians, nurse practitioners, medspas, regenerative medicine clinics, orthopedic practices, and hair restoration centers. Clinic enrollment is required prior to first order.

How are exosomes shipped and stored?

Exosome vials are shipped on dry ice via overnight courier to maintain cold-chain integrity. Upon receipt, store at -80C or in liquid nitrogen vapor phase. Post-thaw viability is 95-98% when proper thawing protocols are followed.

What clinical applications are 60B exosomes used for?

The 3DExo+ 60B matrix is used by licensed professionals for facial rejuvenation, IV infusion protocols, joint therapy, hair restoration, post-procedure recovery, and wellness protocols. Specific application decisions are made at provider discretion within their licensed scope of practice.

1 1

Stem Nova

3DExo+™ 60B Exosome Matrix — Topical Cosmetic Biologic for Licensed Professionals

Regular price: $550.00
Regular price
Sale price: $550.00

Tax included. Shipping calculated at checkout.

About This Product

3DExo+™ Matrix is a topical cosmetic exosome biologic supplied exclusively to licensed medical professionals. Each 1mL vial contains 60 billion NTA-verified extracellular vesicles derived from 3D bioreactor-cultured Wharton's Jelly UCT-MSCs, sourced from an AATB-accredited, FDA-registered tissue establishment operating under cGTP standards (21 CFR Part 1271).

For topical cosmetic use only. Not for injection or therapeutic use. Not FDA-approved.

Why 3D Bioreactor Culture

Most exosome products are produced using standard 2D flat-surface cell culture. Stem Nova Network uses 3D hollow-fiber bioreactor systems that allow cells to grow in three dimensions. Published research has documented up to 19.4x higher extracellular vesicle yield per cell from 3D bioreactor systems compared to conventional 2D flat culture. This is a manufacturing process distinction, not a clinical outcomes claim.

Product Specifications

60 Billion EVs per vial — NTA-verified particle count, lot-documented
3D bioreactor-cultured source cells — Wharton's Jelly UCT-MSC origin
First-pregnancy donors — full donor screening on record
Liquid cryopreserved — not lyophilized, membrane integrity maintained
Xeno-Free · Serum-Free · Endotoxin-tested
Cell-free matrix — no live or viable cells
Sourced from an AATB-accredited, FDA-registered tissue establishment operating under cGTP standards (21 CFR Part 1271)
Lot-specific Certificate of Analysis with every order
Sterility tested per 21 CFR 610.12 · Mycoplasma tested prior to release

Quality & Testing

Every lot is independently tested and released with a Certificate of Analysis covering particle count via NTA, sterility, mycoplasma, endotoxin, and size distribution. Documentation is available upon request before purchase.

Sourcing from an AATB-accredited, FDA-registered tissue establishment operating under cGTP standards (21 CFR Part 1271) are manufacturing and facility credentials. They do not constitute FDA approval of this product for any therapeutic indication.

How to Order

3DExo+™ is available to licensed medical professionals only. Credential verification is required prior to purchase.

Apply for wholesale access at stemnovanetwork.com/apps/wpdapp
Credential verification completed within 24 hours in most cases
Once approved, wholesale pricing and volume tiers are unlocked immediately
Lot-specific CoA provided with every order

Contact partners@stemnovanetwork.com or call 281-541-0047 with any questions.

Frequently Asked Questions

What is the shelf life and storage requirement?
3DExo+™ ships liquid cryopreserved on dry ice. Store at -80°C or below upon receipt. Once thawed, use within the window specified on your lot CoA. Do not refreeze after thawing.

Is a Certificate of Analysis included with every order?
Yes. Every wholesale order includes a lot-specific CoA covering NTA particle count, sterility, mycoplasma, endotoxin, and size distribution. Documentation is also available on request before purchase.

What is NTA verification and why does it matter?
Nanoparticle Tracking Analysis is the gold standard method for confirming actual particle count and size distribution in an exosome preparation. NTA-verified counts reflect what is in the vial as shipped — not estimated or derived figures.

What is the difference between 3D bioreactor and 2D flat culture?
2D flat-plate culture grows cells on a flat surface — the standard method but one that does not replicate natural cellular conditions. 3D bioreactor culture allows cells to grow three-dimensionally. Published research documents up to 19.4x higher EV yield per cell from 3D systems. This is a manufacturing process characteristic documented by independent research.

Is this product FDA-approved?
No. 3DExo+™ is not an FDA-approved drug or therapeutic agent. There are currently no FDA-approved exosome products. This product is supplied as a research-grade cosmetic biologic for licensed professional topical use only.

Regulatory Notice

This product is supplied as a research-grade cosmetic biologic for licensed professional use only. It is not an FDA-approved drug or therapeutic agent and is not intended to diagnose, treat, cure, or prevent any disease or condition. For topical cosmetic use only. Not for injection or therapeutic use. All professional application decisions are at the sole discretion of the licensed practitioner in accordance with applicable federal and state regulations.