Dermal Papillary Secretome Matrix+ with Growth Factors (150bn Exosomes per vial)

150 Billion Exosomes | 1.8 mL Vial

Product Overview

Dermal Papillary Secretome Matrix+ is an ultra-potent cosmetic exosome matrix engineered to rejuvenate the papillary dermal layer—the home of fibroblasts, capillaries, and collagen fibres responsible for youthful skin. Produced from ethically screened donor cells using an advanced three-dimensional (3D) bioreactor process, each 1.8 mL vial contains 150 billion extracellular vesicles (EVs) along with a naturally occurring matrix of growth factors (FGF, VEGF, PDGF, TGF-β), cytokines, peptides, and signalling molecules.

A hollow-fibre 3D system can generate up to 19.4-fold more exosomes and 15.5-fold higher concentrations than conventional 2D flasks, giving this formulation unmatched potency and purity. This cell-free, non-viable matrix is designed exclusively for topical cosmetic use by licensed professionals.

Key Features

• Ultra-High Exosome Potency
  Delivers 150 billion exosomes per vial, providing more than twice the EV load of standard 60 B exosome serums for stronger dermal signalling and regeneration.
• Dermal Papillary-Targeted Matrix
  Enriched with growth factors (FGF, VEGF, PDGF, TGF-β) that stimulate angiogenesis and myofibroblast conversion, enhancing microvascular support and collagen remodelling in the papillary dermis.
• Enhanced Collagen & ECM Support
  Exosomes upregulate genes such as COL3A1, MMP1, and MMP3, converting fibroblasts to myofibroblasts and promoting scarless collagen deposition. Young fibroblast-derived exosomes can elevate collagen I deposition, leading to a healthier extracellular matrix and improved skin resilience.
• Fibroblast Activation & Angiogenesis
  Fibroblast-derived exosomes increase fibroblast migration and proliferation and enhance endothelial cell tube formation while boosting VEGF and CD31 expression, supporting healthy microvasculature and tissue renewal.
• Anti-Wrinkle & Photodamage Support
  In vivo studies show topical exosome application increases collagen expression, decreases matrix metalloproteinases, enhances fibroblast proliferation, and improves wrinkle appearance within weeks. Exosomes also reduce inflammation and promote ceramide synthesis, contributing to smoother, better-hydrated skin.
• Skin Texture, Tone & Elasticity
  Stem-cell-derived exosomes stimulate collagen and elastin synthesis, proliferate dermal fibroblasts, and decrease pro-inflammatory cytokines, resulting in firmer, more even-toned skin.
• Ideal for Post-Procedure Recovery
  Provides powerful topical support after microneedling, RF microneedling, laser resurfacing, or chemical peels to reduce downtime and enhance results.

Intended Use

For topical cosmetic and wellness support applications only, including skin appearance enhancement and post-procedure cosmetic recovery protocols. This product is not for injection and is not intended to diagnose, treat, cure, or prevent any disease.

Recommended Professional Applications

• Microneedling & RF Microneedling – Apply topically immediately after treatment.
• Laser Resurfacing Support – Use post-procedure (CO₂, Er:YAG, fractional lasers).
• Chemical Peel Post-Care – Apply during recovery to calm and repair skin.
• Post-PRP/PRFM & PRF – Enhance regenerative protocols with a topical exosome infusion.
• Stand-Alone Cosmetic Rejuvenation – For clients seeking non-invasive skin revitalisation.

Quality, Testing & Compliance

• Cosmetic classification under the Federal Food, Drug and Cosmetic Act – this product is not FDA-approved as a drug or biologic and is not intended for therapeutic use.
• Manufactured under cosmetic GMP (ISO 22716) in FDA-registered, ISO-compliant facilities. Each lot is tested for sterility (no growth), mycoplasma (negative), and endotoxin (< 0.005 EU/mL).
• Ingredients are listed per INCI standards (21 CFR 701). Formulation is xeno-free and serum-free.
• Traceability systems ensure documented quality and donor screening.

Why Clinics Choose Dermal Papillary Secretome Matrix+

Clinics seeking high potency, biological fidelity, and dermal-specific rejuvenation choose Dermal Papillary Secretome Matrix+ over conventional exosome serums. Our 3D-cultured, non-lyophilised platform yields vastly higher exosome concentrations—up to 19.4× more than 2D cultures—while preserving native membrane integrity and bioactive cargo. The targeted dermal papillary matrix delivers a rich profile of growth factors and signalling molecules that support collagen synthesis, angiogenesis, and ECM remodelling. With rigorous manufacturing standards and clear cosmetic classification, Dermal Papillary Secretome Matrix+ offers predictable handling and premium cosmetic outcomes for post-procedure recovery and stand-alone skin rejuvenation.