Dermal Exosome Matrix 150B — Skin Rejuvenation for Medspas

150 Billion Dermal Exosomes for Medspas & Aesthetic Clinics | 1.8 mL Vial | USA-Made

Dermal Papillary Secretome Matrix+ is the most potent dermal exosome matrix available to licensed aesthetic professionals in the United States. Each 1.8 mL vial delivers 150 billion 3D-cultured extracellular vesicles — more than twice the exosome load of standard 60B serums — along with a naturally occurring matrix of growth factors, cytokines, peptides, and signalling molecules targeted specifically at the papillary dermal layer where collagen, fibroblasts, and microvasculature live.

If your medspa or aesthetic clinic is looking for a topical exosome product that delivers visibly superior results for your patients after microneedling, laser resurfacing, chemical peels, or stand-alone rejuvenation protocols — this is it.

Why the Papillary Dermis Matters

The papillary dermis is the uppermost layer of the dermis — home to the fibroblasts, capillaries, and collagen fibres responsible for youthful, resilient skin. As we age this layer thins, collagen degrades, and microvascular support declines. Dermal Papillary Secretome Matrix+ is specifically engineered to target this layer, delivering growth factors including FGF, VEGF, PDGF, and TGF-β that directly stimulate fibroblast activation, angiogenesis, and collagen remodelling where it matters most.

Why 3D Culturing Produces a Superior Product

Our hollow-fibre 3D bioreactor system generates up to 20x more exosomes and 15.5x higher concentrations than conventional 2D flask culture methods. This means every vial of Dermal Papillary Secretome Matrix+ contains a vastly richer bioactive payload than anything produced through standard manufacturing — and because we never freeze-dry our products, the native membrane integrity and full bioactive cargo is preserved from our lab to your treatment room.

Key Features

• 150 Billion Exosomes Per Vial — NTA-verified, more than 2x the EV load of standard 60B serums
• 3D Bioreactor Cultured — up to 20x more potent than 2D-cultured alternatives
• Dermal Papillary Targeted — enriched with FGF, VEGF, PDGF, TGF-β for collagen and ECM remodelling
• Never Freeze-Dried — fresh, non-lyophilized to preserve full bioactive cargo
• Fibroblast Activation — upregulates COL3A1, MMP1, MMP3 for scarless collagen deposition
• Angiogenesis Support — boosts VEGF and CD31 expression for healthy microvasculature
• Anti-Wrinkle & Photodamage — clinically studied to increase collagen, reduce MMPs, improve wrinkle appearance
• Xeno-Free & Serum-Free — no animal components at any stage of manufacturing
• FDA-Registered Facility — manufactured in a cGMP, ISO 22716-aligned, FDA-registered lab in the USA
• Full Lot Testing — sterility, mycoplasma, and endotoxin tested before every release

Clinical Applications for Licensed Professionals

Dermal Papillary Secretome Matrix+ integrates seamlessly into existing medspa and aesthetic clinic protocols:

• Microneedling & RF Microneedling — apply topically immediately post-treatment for enhanced results and reduced downtime
• Laser Resurfacing — post-procedure support for CO₂, Er:YAG, and fractional laser treatments
• Chemical Peel Recovery — apply during recovery phase to calm inflammation and accelerate repair
• Post-PRP/PRFM Enhancement — layer topical exosomes over regenerative protocols for amplified outcomes
• Stand-Alone Skin Rejuvenation — for patients seeking non-invasive collagen stimulation and anti-aging support
• Hair Restoration Scalp Protocols — fibroblast activation and angiogenesis support for scalp health

What the Science Shows

• Exosomes upregulate collagen genes COL3A1, MMP1, and MMP3, converting fibroblasts to myofibroblasts and promoting scarless collagen deposition
• Young fibroblast-derived exosomes elevate collagen I deposition for a healthier, more resilient extracellular matrix
• In vivo studies show topical exosome application increases collagen expression, decreases matrix metalloproteinases, and improves wrinkle appearance within weeks
• Stem cell-derived exosomes stimulate elastin synthesis, proliferate dermal fibroblasts, and decrease pro-inflammatory cytokines resulting in firmer, more even-toned skin
• Fibroblast-derived exosomes enhance endothelial cell tube formation while boosting VEGF and CD31 expression supporting healthy microvasculature and tissue renewal

Quality, Testing & Compliance

• Cosmetic classification under the Federal Food, Drug, and Cosmetic Act (21 U.S.C. § 301)
• Manufactured under cosmetic GMP (ISO 22716-aligned)
• FDA-registered, ISO-compliant facility — USA manufactured
• Xeno-free and serum-free formulation
• Ingredients listed per INCI standards (21 CFR 701)
• Each lot tested and documented:
  • Sterility: No growth
  • Mycoplasma: Negative
  • Endotoxin: <0.005 EU/mL
  • Exosome count: NTA-verified at 150 billion per vial
• Full traceability systems with documented donor screening

This product is not FDA-approved as a drug or biologic and is not intended to diagnose, treat, cure, or prevent any disease. For topical cosmetic use by licensed professionals only.

How to Order

Dermal Papillary Secretome Matrix+ is available exclusively to licensed medical professionals, medspas, and aesthetic clinics. Enroll your clinic through our professional portal to access pricing and place orders. Volume pricing available for orders of 3 or more vials.

Frequently Asked Questions

How does 150B compare to your 60B exosome product? The 150B Dermal product contains 2.5x more exosomes per vial and is specifically formulated for dermal and aesthetic applications — targeting the papillary dermis with growth factors optimized for collagen, elastin, and microvasculature support. The 60B 3DExo+™ is a broader-spectrum matrix suited for general regenerative and wellness protocols. For purely aesthetic and skin rejuvenation applications, the 150B is the stronger choice.

How many treatments can I get per vial? The 1.8 mL vial is designed for one full-face treatment session. For smaller treatment areas such as periorbital or lip zones, the vial can support 2–3 localized applications.

When should I apply it in my protocol? For post-procedure protocols, apply immediately after microneedling, laser, or chemical peel while the skin barrier is open for maximum absorption. For stand-alone rejuvenation, apply after cleansing and before any occlusive moisturizer.

Is this product freeze-dried? No. Dermal Papillary Secretome Matrix+ is never lyophilized. Freeze-drying degrades membrane integrity and reduces bioactive cargo. Our fresh, liquid formulation preserves the full biological profile from manufacturing to your treatment room.

What is the shelf life? When stored at -20°C, the product maintains full potency for up to 12 months. Once thawed, use within 24–48 hours and do not refreeze.

Is this available to individual consumers? No. This product is sold exclusively to licensed medical professionals, medspas, and aesthetic clinics. Individual consumers seeking treatment are directed to our preferred clinic partners.

Do you offer volume pricing? Yes. Volume pricing is available for orders of 3 or more vials. Enroll your clinic through our professional portal to access tiered pricing and dedicated account support.

For wholesale pricing, clinic enrollment, or product questions contact our team at info@stemnovanetwork.com or call 281-541-0047.