What are 3D-cultured exosomes and why do they outperform 2D-cultured exosomes?

3D-cultured exosomes are produced in hollow-fibre bioreactor systems that mimic the natural cellular environment. This 3D environment generates up to 19.4x more exosomes and 15.5x higher concentrations compared to conventional 2D flat-flask cultures, resulting in a richer, more potent secretome payload for clinical protocols.

Are Stem Nova exosomes FDA approved?

No exosome products are currently FDA approved. Stem Nova exosomes are registered under an FDA Type II Drug Master File (DMF), which documents manufacturing processes and quality controls. Our products are supplied exclusively to licensed medical professionals for use within their professional scope and applicable state regulations.

What testing does each vial of 3DExo+ undergo?

Every vial is tested for: sterility (negative), endotoxin (< 10 EU/mL via LAL per USP 85), mycoplasma (negative), particle count via NTA (Nano Tracking Analysis), and lot-specific release criteria. Products are double-lab tested in-house and through an independent third-party laboratory.

Who can order 3DExo+ 60B exosomes from Stem Nova Network?

Products are available exclusively to licensed medical professionals including physicians, nurse practitioners, medspas, regenerative medicine clinics, orthopedic practices, and hair restoration centers. Clinic enrollment is required prior to first order.

How are exosomes shipped and stored?

Exosome vials are shipped on dry ice via overnight courier to maintain cold-chain integrity. Upon receipt, store at -80C or in liquid nitrogen vapor phase. Post-thaw viability is 95-98% when proper thawing protocols are followed.

What clinical applications are 60B exosomes used for?

The 3DExo+ 60B matrix is used by licensed professionals for facial rejuvenation, IV infusion protocols, joint therapy, hair restoration, post-procedure recovery, and wellness protocols. Specific application decisions are made at provider discretion within their licensed scope of practice.

1 1

Stem Nova

3DExo+™ 60B Exosome Matrix — For Licensed Clinics & Medspas

Regular price: $550.00
Regular price
Sale price: $550.00

Tax included. Shipping calculated at checkout.

60 Billion 3D-Cultured Exosomes for Clinics | 1 mL Vial | USA-Made

3DExo+™ is the most potent exosome matrix available to licensed medical professionals in the United States. Derived from Wharton's Jelly UCT-MSCs and produced through an advanced 3D bioreactor platform, each vial delivers 60 billion verified exosomes — giving your clinic a biologic that performs at a level conventional 2D-cultured or freeze-dried products simply cannot match.

Whether you're running a medspa, orthopedic clinic, hair restoration practice, or regenerative medicine center, 3DExo+™ is built to integrate seamlessly into your existing protocols and deliver consistent, repeatable results for your patients.

Why 3D Culturing Makes All the Difference

Most exosome suppliers use traditional 2D flat-surface cell culture. At Stem Nova Network we use 3D bioreactor systems that mimic the body's natural cellular environment. The result is up to 20x more secretome output per cell — meaning more growth factors, more cytokines, and more bioactive cargo in every single vial.

This isn't a marketing claim. It's the science behind why clinics that switch to 3DExo+™ report more consistent outcomes compared to standard exosome preparations.

Key Features

60 Billion Exosomes Per Vial — NTA-verified count, not estimated
3D Bioreactor Cultured — up to 20x more potent than 2D-cultured alternatives
Wharton's Jelly UCT-MSC Source — first-pregnancy umbilical cord tissue donors, highest biological activity
Never Freeze-Dried — fresh, non-lyophilized to preserve native membrane integrity and full bioactive cargo
Xeno-Free & Serum-Free — no animal components at any stage of manufacturing
Cell-Free Matrix — no live or viable cells, clean and stable for professional use
FDA-Registered Facility — manufactured in a cGMP, ISO-aligned, FDA-registered lab in the USA
Full Lot Testing — every batch tested for sterility, mycoplasma, and endotoxin before release

Clinical Applications

Licensed professionals use 3DExo+™ across a wide range of protocols including:

Post-procedure skin recovery and aesthetic rejuvenation
Hair restoration and scalp regeneration protocols
Joint and orthopedic topical support
Anti-aging and longevity wellness programs
Post-laser, microneedling, and RF treatment recovery
Autoimmune and inflammatory skin support

Quality, Testing & Compliance

Cosmetic classification under the Federal Food, Drug, and Cosmetic Act (21 U.S.C. § 301)
Manufactured under cosmetic GMP (ISO 22716-aligned)
Type II Drug Master File (DMF) certified process
AATB accredited sourcing standards
Each lot tested and documented:
- Sterility: No growth
- Mycoplasma: Negative
- Endotoxin: <0.005 EU/mL
- Exosome count: NTA-verified at 60 billion per vial

All biologics are manufactured to injectable quality standards and labeled for topical and research use only, unless used under appropriate physician discretion or applicable law including Right to Try provisions.

How to Order

3DExo+™ is available exclusively to licensed medical professionals, clinics, and medspas. To access pricing and place orders, enroll your clinic through our professional portal. Volume pricing is available for practices ordering 3 or more vials.

Frequently Asked Questions

What is the shelf life of 3DExo+™? When stored properly at -20°C, 3DExo+™ maintains full potency and viability for up to 12 months. Once thawed, use within 24–48 hours and do not refreeze.

How many treatments can I get per vial? This depends on your protocol and application area. Most practitioners use one vial per treatment session for full-face or scalp applications. For localized treatments, a single vial can support multiple smaller applications.

How does 3DExo+™ compare to PRP? PRP relies on the patient's own platelet concentration which varies significantly between individuals. 3DExo+™ delivers a standardized, consistent 60 billion exosomes per vial every time — no patient variability, no centrifuge equipment needed, and a significantly richer growth factor and cytokine profile.

Is 3DExo+™ available to non-licensed individuals? No. This product is sold exclusively to licensed medical professionals, clinics, and medspas. Individual consumers are directed to our preferred clinic partners for treatment administration.

What makes Stem Nova Network different from other exosome suppliers? Three things: our 3D bioreactor platform produces up to 20x more secretome than standard 2D methods, our products are never freeze-dried which preserves full bioactive integrity, and every lot comes with documented testing results so you know exactly what you're getting before it reaches your patients.

Do you offer volume pricing for clinics? Yes. Volume pricing is available for orders of 3 or more vials. Enroll your clinic through our professional portal to access tiered pricing.

For questions about wholesale pricing, clinic enrollment, or product specifications contact our team at info@stemnovanetwork.com or call 281-541-0047.