{"product_id":"dermal-papillary-secretome-matrix-150b","title":"Dermal Papillary Secretome Matrix+ 150B — Topical Cosmetic Biologic for Licensed Professionals","description":"\u003ch2\u003eAbout This Product\u003c\/h2\u003e\n\u003cp\u003eDermal Papillary Secretome Matrix+ is a topical cosmetic exosome biologic \nsupplied exclusively to licensed medical professionals. Each 1.8mL vial \ncontains 150 billion NTA-verified extracellular vesicles derived from 3D \nbioreactor-cultured Wharton's Jelly UCT-MSCs, sourced from an AATB-accredited, \nFDA-registered tissue establishment operating under cGTP standards \n(21 CFR Part 1271).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor topical cosmetic use only. Not for injection or therapeutic \nuse. Not FDA-approved.\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003ch2\u003eAbout This Formulation\u003c\/h2\u003e\n\u003cp\u003eDermal Papillary Secretome Matrix+ is formulated for the papillary dermal \nlayer — the uppermost layer of the dermis where fibroblasts, capillaries, \nand collagen fibres reside. The 1.8mL volume provides broader coverage than \nstandard 1mL exosome serums and delivers 150 billion NTA-verified EVs — \nmore than twice the EV load of standard 60B formats.\u003c\/p\u003e\n\u003cp\u003eDesigned for use with existing medspa and aesthetic workflows including \nmicroneedling, RF microneedling, laser resurfacing support, and post-procedure \ncosmetic recovery protocols.\u003c\/p\u003e\n\n\u003ch2\u003eWhy 3D Bioreactor Culture\u003c\/h2\u003e\n\u003cp\u003eStem Nova Network uses 3D hollow-fiber bioreactor systems rather than \nstandard 2D flat-surface cell culture. Published research has documented \nup to 19.4x higher extracellular vesicle yield per cell from 3D bioreactor \nsystems compared to conventional 2D flat culture. This is a manufacturing \nprocess distinction, not a clinical outcomes claim.\u003c\/p\u003e\n\u003cp\u003eProducts are liquid cryopreserved — not lyophilized — maintaining \nmembrane integrity from manufacture through delivery.\u003c\/p\u003e\n\n\u003ch2\u003eProduct Specifications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e150 Billion EVs per vial — NTA-verified particle count, lot-documented\u003c\/li\u003e\n\u003cli\u003eVolume: 1.8mL — suitable for full-area cosmetic protocols\u003c\/li\u003e\n\u003cli\u003e3D bioreactor-cultured source cells — Wharton's Jelly UCT-MSC origin\u003c\/li\u003e\n\u003cli\u003eFirst-pregnancy donors — full donor screening on record\u003c\/li\u003e\n\u003cli\u003eLiquid cryopreserved — not lyophilized\u003c\/li\u003e\n\u003cli\u003eXeno-Free · Serum-Free · Endotoxin-tested\u003c\/li\u003e\n\u003cli\u003eCell-free matrix — no live or viable cells\u003c\/li\u003e\n\u003cli\u003eSourced from an AATB-accredited, FDA-registered tissue establishment \noperating under cGTP standards (21 CFR Part 1271)\u003c\/li\u003e\n\u003cli\u003eLot-specific Certificate of Analysis with every order\u003c\/li\u003e\n\u003cli\u003eSterility tested per 21 CFR 610.12 · Mycoplasma tested prior to release\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eCosmetic Application Context\u003c\/h2\u003e\n\u003cp\u003eLicensed professionals incorporate this product into topical cosmetic \nworkflows including:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePost-microneedling topical application\u003c\/li\u003e\n\u003cli\u003ePost-RF microneedling cosmetic support\u003c\/li\u003e\n\u003cli\u003ePost-laser resurfacing cosmetic recovery\u003c\/li\u003e\n\u003cli\u003ePost-chemical peel topical support\u003c\/li\u003e\n\u003cli\u003eStand-alone topical cosmetic facial protocols\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAll professional application decisions are at the sole discretion of the \nlicensed practitioner.\u003c\/p\u003e\n\n\u003ch2\u003eQuality \u0026amp; Testing\u003c\/h2\u003e\n\u003cp\u003eEvery lot is independently tested and released with a Certificate of \nAnalysis covering particle count via NTA, sterility, mycoplasma, endotoxin, \nand size distribution. Documentation is available upon request before \npurchase.\u003c\/p\u003e\n\u003cp\u003eSourcing from an AATB-accredited, FDA-registered tissue establishment \noperating under cGTP standards (21 CFR Part 1271) are manufacturing and \nfacility credentials. They do not constitute FDA approval of this product \nfor any indication.\u003c\/p\u003e\n\n\u003ch2\u003eHow to Order\u003c\/h2\u003e\n\u003cp\u003eDermal Papillary Secretome Matrix+ is available to licensed medical \nprofessionals only. Credential verification is required prior to purchase.\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eApply for wholesale access at stemnovanetwork.com\/apps\/wpdapp\u003c\/li\u003e\n\u003cli\u003eCredential verification completed within 24 hours in most cases\u003c\/li\u003e\n\u003cli\u003eOnce approved, wholesale pricing and volume tiers are unlocked \nimmediately\u003c\/li\u003e\n\u003cli\u003eLot-specific CoA provided with every order\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003eContact partners@stemnovanetwork.com or call 281-541-0047 with any \nquestions.\u003c\/p\u003e\n\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eWhat is the shelf life and storage requirement?\u003c\/strong\u003e\u003cbr\u003e\nShips liquid cryopreserved on dry ice. Store at -80°C or below upon receipt. \nOnce thawed, use within the window specified on your lot CoA. Do not \nrefreeze after thawing.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eIs a Certificate of Analysis included with every order?\u003c\/strong\u003e\u003cbr\u003e\nYes. Every wholesale order includes a lot-specific CoA covering NTA particle \ncount, sterility, mycoplasma, endotoxin, and size distribution. Documentation \nis available on request before purchase as well.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eHow does the 150B differ from the 3DExo+™ 60B?\u003c\/strong\u003e\u003cbr\u003e\nThe 150B vial contains 150 billion NTA-verified EVs in a 1.8mL volume — \nmore than twice the EV count of the 60B vial and a larger volume for broader \ncoverage. Both are topical cosmetic exosome biologics for licensed \nprofessional use only.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eIs this product FDA-approved?\u003c\/strong\u003e\u003cbr\u003e\nNo. This product is not an FDA-approved drug or therapeutic agent. There are \ncurrently no FDA-approved exosome products. This product is supplied as a \nresearch-grade cosmetic biologic for licensed professional topical use only.\u003c\/p\u003e\n\n\u003ch2\u003eRegulatory Notice\u003c\/h2\u003e\n\u003cp\u003eThis product is supplied as a research-grade cosmetic biologic for licensed \nprofessional use only. It is not an FDA-approved drug or therapeutic agent \nand is not intended to diagnose, treat, cure, or prevent any disease or \ncondition. For topical cosmetic use only. Not for injection or therapeutic \nuse. All professional application decisions are at the sole discretion of \nthe licensed practitioner in accordance with applicable federal and state \nregulations.\u003c\/p\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"Product\",\n  \"name\": \"Dermal Papillary Secretome Matrix+ — 150 Billion EVs\",\n  \"description\": \"Ultra-potent topical cosmetic exosome biologic. 150 billion NTA-verified EVs. 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